Myocardial Drug Distribution Generated from Local Epicardial Application: Potential Impact of Cardiac Capillary Perfusion in a Swine Model Using Epinephrine

Prior studies in small mammals have shown that local epicardial application of inotropic compounds drives myocardial contractility without systemic side effects. Myocardial capillary blood flow, however, may be more significant in larger species than in small animals. We hypothesized that bulk perfu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Control Release
Hauptverfasser: Maslov, Mikhail Y., Edelman, Elazer R., Pezone, Matthew J., Wei, Abraham E., Wakim, Matthew G., Murray, Michael R., Tsukada, Hisashi, Gerogiannis, Iraklis S., Groothuis, Adam, Lovich, Mark A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252373/
https://ncbi.nlm.nih.gov/pubmed/25234821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.09.012
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge