Myocardial Drug Distribution Generated from Local Epicardial Application: Potential Impact of Cardiac Capillary Perfusion in a Swine Model Using Epinephrine

Prior studies in small mammals have shown that local epicardial application of inotropic compounds drives myocardial contractility without systemic side effects. Myocardial capillary blood flow, however, may be more significant in larger species than in small animals. We hypothesized that bulk perfu...

Full description

Saved in:
Bibliographic Details
Published in:J Control Release
Main Authors: Maslov, Mikhail Y., Edelman, Elazer R., Pezone, Matthew J., Wei, Abraham E., Wakim, Matthew G., Murray, Michael R., Tsukada, Hisashi, Gerogiannis, Iraklis S., Groothuis, Adam, Lovich, Mark A.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252373/
https://ncbi.nlm.nih.gov/pubmed/25234821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.09.012
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items