The N-Terminal Fragment of a PB2 Subunit from the Influenza A Virus (A/Hong Kong/156/1997 H5N1) Effectively Inhibits RNP Activity and Viral Replication

BACKGROUND: Influenza A virus has a RNA-dependent RNA polymerase (RdRp) that is composed of three subunits (PB1, PB2 and PA subunit), which assemble with nucleoproteins (NP) and a viral RNA (vRNA) to form a RNP complex in the host nucleus. Recently, we demonstrated that the combination of influenza...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kashiwagi, Takahito, Hara, Koyu, Nakazono, Yoko, Uemura, Yusaku, Imamura, Yoshihiro, Hamada, Nobuyuki, Watanabe, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252148/
https://ncbi.nlm.nih.gov/pubmed/25460916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114502
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