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Artificial hybrids of influenza A virus RNA polymerase reveal PA subunit modulates its thermal sensitivity.

BACKGROUND: Influenza A virus can infect a variety of different hosts and therefore has to adapt to different host temperatures for its efficient viral replication. Influenza virus codes for an RNA polymerase of 3 subunits: PB1, PB2 and PA. It is well known that the PB2 subunit is involved in temper...

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Autors principals: Takahito Kashiwagi, Koyu Hara, Yoko Nakazono, Nobuyuki Hamada, Hiroshi Watanabe
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2010-01-01
Col·lecció:PLoS ONE
Accés en línia:http://europepmc.org/articles/PMC2998429?pdf=render
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