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Sensitivity of leukemic T-cell lines to arsenic trioxide cytotoxicity is dependent on the induction of phosphatase B220/CD45R expression at the cell surface

BACKGROUND: Arsenic trioxide (As(2)O(3)) is highly effective in treating acute promyelocytic leukemia (APL), but shows more variable therapeutic efficacy for other types of hematological malignancies. Previously, we reported that As(2)O(3) selectively eliminates pathogenic B220-expressing T cells in...

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Bibliografische gegevens
Gepubliceerd in:Mol Cancer
Hoofdauteurs: Benbijja, Mohcine, Mellouk, Amine, Bobé, Pierre
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252024/
https://ncbi.nlm.nih.gov/pubmed/25410152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-251
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