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Human insulin B24 (Phe----Ser). Secretion and metabolic clearance of the abnormal insulin in man and in a dog model.

We have already demonstrated that a hyperinsulinemic, diabetic subject secreted an abnormal insulin in which serine replaced phenylalanine B24 (Shoelson S., M. Fickova, M. Haneda, A. Nahum, G. Musso, E. T. Kaiser, A. H. Rubenstein, and H. Tager. 1983. Proc. Natl. Acad. Sci. USA. 80:7390-7394). High...

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Udgivet i:J Clin Invest
Principais autores: Shoelson, S E, Polonsky, K S, Zeidler, A, Rubenstein, A H, Tager, H S
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC425157/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6371057/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111338
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