The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study

OBJECTIVE: Variation in the fat mass and obesity-associated (FTO) gene influences susceptibility to obesity. A variant in the FTO gene has been implicated in genetic risk to osteoarthritis (OA). We examined the role of the FTO polymorphism rs8044769 in risk of knee and hip OA in cases and controls i...

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Udgivet i:Ann Rheum Dis
Main Authors: Panoutsopoulou, Kalliope, Metrustry, Sarah, Doherty, Sally A, Laslett, Laura L, Maciewicz, Rose A, Hart, Deborah J, Zhang, Weiya, Muir, Kenneth R, Wheeler, Margaret, Cooper, Cyrus, Spector, Tim D, Cicuttini, Flavia M, Jones, Graeme, Arden, Nigel K, Doherty, Michael, Zeggini, Eleftheria, Valdes, Ana M
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2014
Fag:
Clinical and Epidemiological Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4251538/
https://ncbi.nlm.nih.gov/pubmed/23921993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2013-203772
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