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Tumor Cell–Targeted Delivery of Nanoconjugated Oligonucleotides in Composite Spheroids

Standard tissue culture has often been a poor model for predicting the efficacy of anti-cancer agents including oligonucleotides. In contrast to the simplicity of monolayer tissue cultures, a tumor mass includes tightly packed tumor cells, tortuous blood vessels, high levels of extracellular matrix,...

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Detalhes bibliográficos
Publicado no:Nucleic Acid Ther
Main Authors: Carver, Kyle, Ming, Xin, Juliano, Rudy L.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250944/
https://ncbi.nlm.nih.gov/pubmed/25238564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2014.0493
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