Intracellular Na(+) Overload Causes Oxidation of CaMKII and leads to Ca(2+) Mishandling in Isolated Ventricular Myocytes

AIM: An increase of late sodium Na(+) current (I(NaL)) in cardiac myocytes can raise the cytosolic Na(+) concentration and is associated with activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and alterations of mitochondrial metabolism and Ca(2+) handling by sarcoplasmic reticulum...

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Published in:J Mol Cell Cardiol
Main Authors: Viatchenko-Karpinski, Serge, Kornyeyev, Dmytro, El-Bizri, Nesrine, Budas, Grant, Fan, Peidong, Jiang, Zhan, Yang, Jin, Anderson, Mark E., Shryock, John C., Chang, Ching-Pin, Belardinelli, Luiz, Yao, Lina
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250389/
https://ncbi.nlm.nih.gov/pubmed/25252177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.09.009
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