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Sample processing obscures cancer-specific alterations in leukemic transcriptomes

Substantial effort is currently devoted to identifying cancer-associated alterations using genomics. Here, we show that standard blood collection procedures rapidly change the transcriptional and posttranscriptional landscapes of hematopoietic cells, resulting in biased activation of specific biolog...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dvinge, Heidi, Ries, Rhonda E., Ilagan, Janine O., Stirewalt, Derek L., Meshinchi, Soheil, Bradley, Robert K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250124/
https://ncbi.nlm.nih.gov/pubmed/25385641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413374111
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