Potential function for the Huntingtin protein as a scaffold for selective autophagy

Although dominant gain-of-function triplet repeat expansions in the Huntingtin (HTT) gene are the underlying cause of Huntington disease (HD), understanding the normal functions of nonmutant HTT protein has remained a challenge. We report here findings that suggest that HTT plays a significant role...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Ochaba, Joseph, Lukacsovich, Tamás, Csikos, George, Zheng, Shuqiu, Margulis, Julia, Salazar, Lisa, Mao, Kai, Lau, Alice L., Yeung, Sylvia Y., Humbert, Sandrine, Saudou, Frédéric, Klionsky, Daniel J., Finkbeiner, Steven, Zeitlin, Scott O., Marsh, J. Lawrence, Housman, David E., Thompson, Leslie M., Steffan, Joan S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250109/
https://ncbi.nlm.nih.gov/pubmed/25385587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420103111
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