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DNA topology confers sequence specificity to nonspecific architectural proteins

Topological constraints placed on short fragments of DNA change the disorder found in chain molecules randomly decorated by nonspecific, architectural proteins into tightly organized 3D structures. The bacterial heat-unstable (HU) protein builds up, counter to expectations, in greater quantities and...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wei, Juan, Czapla, Luke, Grosner, Michael A., Swigon, David, Olson, Wilma K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250108/
https://ncbi.nlm.nih.gov/pubmed/25385626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405016111
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