Bispecific antibody generated with sortase and click chemistry has broad antiinfluenza virus activity

Bispecific antibodies have therapeutic potential by expanding the functions of conventional antibodies. Many different formats of bispecific antibodies have meanwhile been developed. Most are genetic modifications of the antibody backbone to facilitate incorporation of two different variable domains...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Wagner, Koen, Kwakkenbos, Mark J., Claassen, Yvonne B., Maijoor, Kelly, Böhne, Martino, van der Sluijs, Koenraad F., Witte, Martin D., van Zoelen, Diana J., Cornelissen, Lisette A., Beaumont, Tim, Bakker, Arjen Q., Ploegh, Hidde L., Spits, Hergen
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250106/
https://ncbi.nlm.nih.gov/pubmed/25385586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408605111
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