Inhibition of Osteoclastogenesis and Inflammatory Bone Resorption by Targeting BET Proteins and Epigenetic Regulation

Emerging evidence suggests that RANKL-induced changes in chromatin state are important for osteoclastogenesis, but these epigenetic mechanisms are not well understood and have not been therapeutically targeted. In this study we find that the small molecule I-BET151 that targets bromo and extra-termi...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Park-Min, Kyung-Hyun, Lim, Elisha, Lee, Min Joon, Park, Sung Ho, Giannopoulos, Eugenia, Yarilina, Anna, van der Meulen, Marjolein, Zhao, Baohong, Smithers, Nicholas, Witherington, Jason, Lee, Kevin, Tak, Paul P., Prinjha, Rab K., Ivashkiv, Lionel B.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249944/
https://ncbi.nlm.nih.gov/pubmed/25391636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6418
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