Peptide nucleic acids targeting β-globin mRNAs selectively inhibit hemoglobin production in murine erythroleukemia cells

In the treatment of hemoglobinopathies, amending altered hemoglobins and/or globins produced in excess is an important part of therapeutic strategies and the selective inhibition of globin production may be clinically beneficial. Therefore the development of drug-based methods for the selective inhi...

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Udgivet i:Int J Mol Med
Main Authors: MONTAGNER, GIULIA, GEMMO, CHIARA, FABBRI, ENRICA, MANICARDI, ALEX, ACCARDO, IGEA, BIANCHI, NICOLETTA, FINOTTI, ALESSIA, BREVEGLIERI, GIULIA, SALVATORI, FRANCESCA, BORGATTI, MONICA, LAMPRONTI, ILARIA, BRESCIANI, ALBERTO, ALTAMURA, SERGIO, CORRADINI, ROBERTO, GAMBARI, ROBERTO
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249754/
https://ncbi.nlm.nih.gov/pubmed/25405921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2014.2005
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