Macrophage and NK-mediated Killing of Precursor-B Acute Lymphoblastic Leukemia Cells Targeted with a-Fucosylated Anti-CD19 Humanized Antibodies

This work reports the tumoricidal effects of a novel investigational humanized anti-CD19 monoclonal antibody (Medi-551). An a-fucosylated antibody with increased affinity for human FcγRIIIA, Medi-551 is shown to mediate both antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP). Me...

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Publicado en:Leukemia
Main Authors: Matlawska-Wasowska, Ksenia, Ward, Elizabeth, Stevens, Samuel, Wang, Yue, Herbst, Ronald, Winter, Stuart S., Wilson, Bridget S.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249624/
https://ncbi.nlm.nih.gov/pubmed/23307031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.5
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