Small-Molecule Inhibitors of the Pseudaminic Acid Biosynthetic Pathway: Targeting Motility as a Key Bacterial Virulence Factor

Helicobacter pylori is motile by means of polar flagella, and this motility has been shown to play a critical role in pathogenicity. The major structural flagellin proteins have been shown to be glycosylated with the nonulosonate sugar, pseudaminic acid (Pse). This glycan is unique to microorganisms...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Ménard, Robert, Schoenhofen, Ian C., Tao, Limei, Aubry, Annie, Bouchard, Patrice, Reid, Christopher W., Lachance, Paule, Twine, Susan M., Fulton, Kelly M., Cui, Qizhi, Hogues, Hervé, Purisima, Enrico O., Sulea, Traian, Logan, Susan M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2014
Onderwerpen:
Experimental Therapeutics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249573/
https://ncbi.nlm.nih.gov/pubmed/25267679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03858-14
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items