Small-Molecule Inhibitors of the Pseudaminic Acid Biosynthetic Pathway: Targeting Motility as a Key Bacterial Virulence Factor

Helicobacter pylori is motile by means of polar flagella, and this motility has been shown to play a critical role in pathogenicity. The major structural flagellin proteins have been shown to be glycosylated with the nonulosonate sugar, pseudaminic acid (Pse). This glycan is unique to microorganisms...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Ménard, Robert, Schoenhofen, Ian C., Tao, Limei, Aubry, Annie, Bouchard, Patrice, Reid, Christopher W., Lachance, Paule, Twine, Susan M., Fulton, Kelly M., Cui, Qizhi, Hogues, Hervé, Purisima, Enrico O., Sulea, Traian, Logan, Susan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249573/
https://ncbi.nlm.nih.gov/pubmed/25267679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03858-14
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