Small-Molecule Inhibitors of the Pseudaminic Acid Biosynthetic Pathway: Targeting Motility as a Key Bacterial Virulence Factor

Helicobacter pylori is motile by means of polar flagella, and this motility has been shown to play a critical role in pathogenicity. The major structural flagellin proteins have been shown to be glycosylated with the nonulosonate sugar, pseudaminic acid (Pse). This glycan is unique to microorganisms...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Ménard, Robert, Schoenhofen, Ian C., Tao, Limei, Aubry, Annie, Bouchard, Patrice, Reid, Christopher W., Lachance, Paule, Twine, Susan M., Fulton, Kelly M., Cui, Qizhi, Hogues, Hervé, Purisima, Enrico O., Sulea, Traian, Logan, Susan M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249573/
https://ncbi.nlm.nih.gov/pubmed/25267679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03858-14
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