Small-Molecule Inhibitors of the Pseudaminic Acid Biosynthetic Pathway: Targeting Motility as a Key Bacterial Virulence Factor

Helicobacter pylori is motile by means of polar flagella, and this motility has been shown to play a critical role in pathogenicity. The major structural flagellin proteins have been shown to be glycosylated with the nonulosonate sugar, pseudaminic acid (Pse). This glycan is unique to microorganisms...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Antimicrob Agents Chemother
Egile Nagusiak: Ménard, Robert, Schoenhofen, Ian C., Tao, Limei, Aubry, Annie, Bouchard, Patrice, Reid, Christopher W., Lachance, Paule, Twine, Susan M., Fulton, Kelly M., Cui, Qizhi, Hogues, Hervé, Purisima, Enrico O., Sulea, Traian, Logan, Susan M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2014
Gaiak:
Experimental Therapeutics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249573/
https://ncbi.nlm.nih.gov/pubmed/25267679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03858-14
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