An In Vitro Deletion in ribE Encoding Lumazine Synthase Contributes to Nitrofurantoin Resistance in Escherichia coli

Nitrofurantoin has been used for decades for the treatment of urinary tract infections (UTIs), but clinically significant resistance in Escherichia coli is uncommon. Nitrofurantoin concentrations in the gastrointestinal tract tend to be low, which might facilitate selection of nitrofurantoin-resista...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Vervoort, Jascha, Xavier, Basil Britto, Stewardson, Andrew, Coenen, Samuel, Godycki-Cwirko, Maciek, Adriaenssens, Niels, Kowalczyk, Anna, Lammens, Christine, Harbarth, Stephan, Goossens, Herman, Malhotra-Kumar, Surbhi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249564/
https://ncbi.nlm.nih.gov/pubmed/25246406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03952-14
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