New Colistin Population Pharmacokinetic Data in Critically Ill Patients Suggesting an Alternative Loading Dose Rationale

Colistin is an old antibiotic that has recently gained a considerable renewal of interest as the last-line defense therapy against multidrug-resistant Gram-negative bacteria. It is administered as colistin methanesulfonate (CMS), an inactive prodrug, and it was shown that due to slow CMS conversion,...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Grégoire, N., Mimoz, O., Mégarbane, B., Comets, E., Chatelier, D., Lasocki, S., Gauzit, R., Balayn, D., Gobin, P., Marchand, S., Couet, W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249546/
https://ncbi.nlm.nih.gov/pubmed/25267662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03508-14
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