Safety and Pharmacokinetic Profiles of Phosphorodiamidate Morpholino Oligomers with Activity against Ebola Virus and Marburg Virus: Results of Two Single-Ascending-Dose Studies

Two identical single-ascending-dose studies evaluated the safety and pharmacokinetics (PK) of AVI-6002 and AVI-6003, two experimental combinations of phosphorodiamidate morpholino oligomers with positive charges (PMOplus) that target viral mRNA encoding Ebola virus and Marburg virus proteins, respec...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Heald, Alison E., Iversen, Patrick L., Saoud, Jay B., Sazani, Peter, Charleston, Jay S., Axtelle, Tim, Wong, Michael, Smith, William B., Vutikullird, Apinya, Kaye, Edward
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249403/
https://ncbi.nlm.nih.gov/pubmed/25155593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03442-14
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