Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques

Marburg virus (MARV) is an Ebola-like virus in the family Filovirdae that causes sporadic outbreaks of severe hemorrhagic fever with a case fatality rate as high as 90%. AVI-7288, a positively charged antisense phosphorodiamidate morpholino oligomer (PMOplus) targeting the viral nucleoprotein gene,...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Warren, Travis K., Whitehouse, Chris A., Wells, Jay, Welch, Lisa, Charleston, Jay S., Heald, Alison, Nichols, Donald K., Mattix, Marc E., Palacios, Gustavo, Kugleman, Jeffrey R., Iversen, Patrick L., Bavari, Sina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764691/
https://ncbi.nlm.nih.gov/pubmed/26901785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004456
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