Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques

Marburg virus (MARV) is an Ebola-like virus in the family Filovirdae that causes sporadic outbreaks of severe hemorrhagic fever with a case fatality rate as high as 90%. AVI-7288, a positively charged antisense phosphorodiamidate morpholino oligomer (PMOplus) targeting the viral nucleoprotein gene,...

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Veröffentlicht in:PLoS Negl Trop Dis
Hauptverfasser: Warren, Travis K., Whitehouse, Chris A., Wells, Jay, Welch, Lisa, Charleston, Jay S., Heald, Alison, Nichols, Donald K., Mattix, Marc E., Palacios, Gustavo, Kugleman, Jeffrey R., Iversen, Patrick L., Bavari, Sina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764691/
https://ncbi.nlm.nih.gov/pubmed/26901785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004456
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