Activation of the RIG-I Pathway during Influenza Vaccination Enhances the Germinal Center Reaction, Promotes T Follicular Helper Cell Induction, and Provides a Dose-Sparing Effect and Protective Immunity

Pattern recognition receptors (PRR) sense certain molecular patterns uniquely expressed by pathogens. Retinoic-acid-inducible gene I (RIG-I) is a cytosolic PRR that senses viral nucleic acids and induces innate immune activation and secretion of type I interferons (IFNs). Here, using influenza vacci...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Kulkarni, Raveendra R., Rasheed, Mohammed Ata Ur, Bhaumik, Siddhartha Kumar, Ranjan, Priya, Cao, Weiping, Davis, Carl, Marisetti, Krishna, Thomas, Sunil, Gangappa, Shivaprakash, Sambhara, Suryaprakash, Murali-Krishna, Kaja
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249139/
https://ncbi.nlm.nih.gov/pubmed/25253340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02273-14
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