Hyperglycosylated Stable Core Immunogens Designed To Present the CD4 Binding Site Are Preferentially Recognized by Broadly Neutralizing Antibodies

The HIV-1 surface envelope glycoprotein (Env) trimer mediates entry into CD4(+) CCR5(+) host cells. Env possesses conserved antigenic determinants, such as the gp120 primary receptor CD4 binding site (CD4bs), a known neutralization target. Env also contains variable regions and protein surfaces occl...

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Bibliographic Details
Published in:J Virol
Main Authors: Ingale, Jidnyasa, Tran, Karen, Kong, Leopold, Dey, Barna, McKee, Krisha, Schief, William, Kwong, Peter D., Mascola, John R., Wyatt, Richard T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249138/
https://ncbi.nlm.nih.gov/pubmed/25253346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02614-14
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