Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.

A set of mutations [Ala-62-->Val(A62V), V75I, F77L, F116Y, and Q151M] in the polymerase domain of reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) confers on the virus a reduced sensitivity to multiple antiretroviral dideoxynucleosides and has been seen in HIV-1 variants iso...

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محفوظ في:

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Proc Natl Acad Sci U S A
المؤلفون الرئيسيون:	Shirasaka, T, Kavlick, M F, Ueno, T, Gao, W Y, Kojima, E, Alcaide, M L, Chokekijchai, S, Roy, B M, Arnold, E, Yarchoan, R
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	National Academy of Sciences 1995
الموضوعات:	Research Article
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42491/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7534421/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.6.2398
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Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.

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