Cholesterol-Dependent Membrane Fusion Induced by the gp41 Membrane-Proximal External Region–Transmembrane Domain Connection Suggests a Mechanism for Broad HIV-1 Neutralization

The HIV-1 glycoprotein 41 promotes fusion of the viral membrane with that of the target cell. Structural, biochemical, and biophysical studies suggest that its membrane-proximal external region (MPER) may interact with the HIV-1 membrane and induce its disruption and/or deformation during the proces...

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Bibliographic Details
Published in:J Virol
Main Authors: Apellániz, Beatriz, Rujas, Edurne, Carravilla, Pablo, Requejo-Isidro, José, Huarte, Nerea, Domene, Carmen, Nieva, José L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249078/
https://ncbi.nlm.nih.gov/pubmed/25210180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02151-14
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