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Stepwise Priming by Acidic pH and a High K(+) Concentration Is Required for Efficient Uncoating of Influenza A Virus Cores after Penetration

Influenza A virus (IAV) uses the low pH in late endocytic vacuoles as a cue for penetration by membrane fusion. Here, we analyzed the prefusion reactions that prepare the core for uncoating after it has been delivered to the cytosol. We found that this priming process occurs in two steps that are me...

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Bibliografski detalji
Izdano u:J Virol
Glavni autori: Stauffer, Sarah, Feng, Yuehan, Nebioglu, Firat, Heilig, Rosalie, Picotti, Paola, Helenius, Ari
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249060/
https://ncbi.nlm.nih.gov/pubmed/25165113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01430-14
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