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Stepwise Priming by Acidic pH and a High K(+) Concentration Is Required for Efficient Uncoating of Influenza A Virus Cores after Penetration

Influenza A virus (IAV) uses the low pH in late endocytic vacuoles as a cue for penetration by membrane fusion. Here, we analyzed the prefusion reactions that prepare the core for uncoating after it has been delivered to the cytosol. We found that this priming process occurs in two steps that are me...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Stauffer, Sarah, Feng, Yuehan, Nebioglu, Firat, Heilig, Rosalie, Picotti, Paola, Helenius, Ari
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249060/
https://ncbi.nlm.nih.gov/pubmed/25165113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01430-14
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