Effects of Human Anti-Spike Protein Receptor Binding Domain Antibodies on Severe Acute Respiratory Syndrome Coronavirus Neutralization Escape and Fitness

The receptor binding domain (RBD) of the spike (S) glycoprotein of severe acute respiratory syndrome coronavirus (SARS-CoV) is a major target of protective immunity in vivo. Although a large number of neutralizing antibodies (nAbs) have been developed, it remains unclear if a single RBD-targeting nA...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Sui, Jianhua, Deming, Meagan, Rockx, Barry, Liddington, Robert C., Zhu, Quan Karen, Baric, Ralph S., Marasco, Wayne A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248992/
https://ncbi.nlm.nih.gov/pubmed/25231316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02232-14
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