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Escape from Human Monoclonal Antibody Neutralization Affects In Vitro and In Vivo Fitness of Severe Acute Respiratory Syndrome Coronavirus

Background. Severe acute respiratory syndrome (SARS) emerged as a human disease in 2002. Detailed phylogenetic analysis and epidemiologic studies have suggested that the SARS coronavirus (SARS-CoV) originated from animals. The spike (S) glycoprotein has been identified as a major target of protectiv...

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Detalhes bibliográficos
Main Authors: Rockx, Barry, Donaldson, Eric, Frieman, Matthew, Sheahan, Timothy, Corti, Davide, Lanzavecchia, Antonio, Baric, Ralph S.
Formato: Artigo
Idioma:Inglês
Publicado em: The University of Chicago Press 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826557/
https://ncbi.nlm.nih.gov/pubmed/20144042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/651022
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