Exonuclease Domain of the Lassa Virus Nucleoprotein Is Critical To Avoid RIG-I Signaling and To Inhibit the Innate Immune Response

Lassa virus (LASV), which causes a viral hemorrhagic fever, inhibits the innate immune response. The exonuclease (ExoN) domain of its nucleoprotein (NP) is implicated in the suppression of retinoic acid-inducible gene I (RIG-I) signaling. We show here that a LASV in which ExoN function has been abol...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Reynard, Stéphanie, Russier, Marion, Fizet, Alexandra, Carnec, Xavier, Baize, Sylvain
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248989/
https://ncbi.nlm.nih.gov/pubmed/25253344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01923-14
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