Lassa Virus Nucleoprotein Mutants Generated by Reverse Genetics Induce a Robust Type I Interferon Response in Human Dendritic Cells and Macrophages

Lassa virus (LASV; Arenaviridae) is responsible for severe hemorrhagic fevers in Africa. LASV nucleoprotein (NP) plays important roles in regulating viral transcription and replication and in inhibiting type I interferon (IFN) production. The NP C-terminal domain contains a 3′-to-5′ exonuclease acti...

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Main Authors: Carnec, Xavier, Baize, Sylvain, Reynard, Stéphanie, Diancourt, Laure, Caro, Valérie, Tordo, Noel, Bouloy, Michèle
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
Assuntos:
Cellular Response to Infection
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209271/
https://ncbi.nlm.nih.gov/pubmed/21880754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00429-11
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