Drift of the HIV-1 Envelope Glycoprotein gp120 toward Increased Neutralization Resistance over the Course of the Epidemic: a Comprehensive Study Using the Most Potent and Broadly Neutralizing Monoclonal Antibodies

Extending our previous analyses to the most recently described monoclonal broadly neutralizing antibodies (bNAbs), we confirmed a drift of HIV-1 clade B variants over 2 decades toward higher resistance to bNAbs targeting almost all the identified gp120-neutralizing epitopes. In contrast, the sensiti...

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Veröffentlicht in:J Virol
Hauptverfasser: Bouvin-Pley, M., Morgand, M., Meyer, L., Goujard, C., Moreau, A., Mouquet, H., Nussenzweig, M., Pace, C., Ho, D., Bjorkman, P. J., Baty, D., Chames, P., Pancera, M., Kwong, P. D., Poignard, P., Barin, F., Braibant, M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248973/
https://ncbi.nlm.nih.gov/pubmed/25231299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02083-14
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