DNA copy number analysis of fresh and formalin-fixed specimens by shallow whole-genome sequencing with identification and exclusion of problematic regions in the genome assembly

Detection of DNA copy number aberrations by shallow whole-genome sequencing (WGS) faces many challenges, including lack of completion and errors in the human reference genome, repetitive sequences, polymorphisms, variable sample quality, and biases in the sequencing procedures. Formalin-fixed paraff...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Genome Res
Κύριοι συγγραφείς: Scheinin, Ilari, Sie, Daoud, Bengtsson, Henrik, van de Wiel, Mark A., Olshen, Adam B., van Thuijl, Hinke F., van Essen, Hendrik F., Eijk, Paul P., Rustenburg, François, Meijer, Gerrit A., Reijneveld, Jaap C., Wesseling, Pieter, Pinkel, Daniel, Albertson, Donna G., Ylstra, Bauke
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Cold Spring Harbor Laboratory Press 2014
Θέματα:
Method
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248318/
https://ncbi.nlm.nih.gov/pubmed/25236618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.175141.114
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