A novel Bcr-Abl–mTOR–eIF4A axis regulates IRES-mediated translation of LEF-1

Internal ribosome entry sites (IRESs) in cellular mRNAs direct expression of growth-promoting factors through an alternative translation mechanism that has yet to be fully defined. Lymphoid enhancer factor-1 (LEF-1), a Wnt-mediating transcription factor important for cell survival and metastasis in...

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Detalhes bibliográficos
Publicado no:Open Biol
Main Authors: Tsai, Becky Pinjou, Jimenez, Judith, Lim, Sharon, Fitzgerald, Kerry D., Zhang, Min, Chuah, Charles T. H., Axelrod, Haley, Nelson, Luke, Ong, S. Tiong, Semler, Bert L., Waterman, Marian L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248067/
https://ncbi.nlm.nih.gov/pubmed/25392452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.140180
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