Functional link between muscarinic receptors and large-conductance Ca(2+)-activated K(+) channels in freshly-isolated human detrusor smooth muscle cells

Activation of muscarinic acetylcholine receptors (mAChRs) constitutes the primary mechanism for enhancing excitability and contractility of human detrusor smooth muscle (DSM). Since the large conductance Ca(2+)-activated K(+) (K(Ca)1.1) channels are key regulators of human DSM function, we investiga...

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Veröffentlicht in:Pflugers Arch
Hauptverfasser: Parajuli, Shankar P., Hristov, Kiril L., Cheng, Qiuping, Malysz, John, Rovner, Eric S., Petkov, Georgi V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4247359/
https://ncbi.nlm.nih.gov/pubmed/24867682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-014-1537-8
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