Global changes in the RNA binding specificity of HIV-1 Gag regulate virion genesis

The HIV-1 Gag protein orchestrates all steps of virion genesis, including membrane targeting and RNA recruitment into virions. Using crosslinking-immunoprecipitation (CLIP) sequencing, we uncover several dramatic changes in the RNA binding properties of Gag that occur during virion genesis, coincide...

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Bibliographic Details
Published in:Cell
Main Authors: Kutluay, Sebla B., Zang, Trinity, Blanco-Melo, Daniel, Powell, Chelsea, Jannain, David, Errando, Manel, Bieniasz, Paul D.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4247003/
https://ncbi.nlm.nih.gov/pubmed/25416948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.09.057
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