Diversity and clonal selection in the human T-cell repertoire

T-cell receptor (TCR) diversity, a prerequisite for immune system recognition of the universe of foreign antigens, is generated in the first two decades of life in the thymus and then persists to an unknown extent through life via homeostatic proliferation of naïve T cells. We have used next-generat...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Qi, Qian, Liu, Yi, Cheng, Yong, Glanville, Jacob, Zhang, David, Lee, Ji-Yeun, Olshen, Richard A., Weyand, Cornelia M., Boyd, Scott D., Goronzy, Jörg J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246948/
https://ncbi.nlm.nih.gov/pubmed/25157137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409155111
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