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Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel
Voltage-gated sodium (Na(v)) channels are important targets in the treatment of a range of pathologies. Bacterial channels, for which crystal structures have been solved, exhibit modulation by local anesthetic and anti-epileptic agents, allowing molecular-level investigations into sodium channel-dru...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4246943/ https://ncbi.nlm.nih.gov/pubmed/25136136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408710111 |
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