Folliculin regulates cell–cell adhesion, AMPK, and mTORC1 in a cell‐type‐specific manner in lung‐derived cells

Germline loss‐of‐function BHD mutations cause cystic lung disease and hereditary pneumothorax, yet little is known about the impact of BHD mutations in the lung. Folliculin (FLCN), the product of the Birt–Hogg–Dube (BHD) gene, has been linked to altered cell–cell adhesion and to the AMPK and mTORC1...

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Vydáno v:Physiol Rep
Hlavní autoři: Khabibullin, Damir, Medvetz, Douglas A., Pinilla, Miguel, Hariharan, Venkatesh, Li, Chenggang, Hergrueter, Anja, Laucho Contreras, Maria, Zhang, Erik, Parkhitko, Andrey, Yu, Jane J., Owen, Caroline A., Huang, Hayden, Baron, Rebecca M., Henske, Elizabeth P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley Periodicals, Inc. 2014
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246594/
https://ncbi.nlm.nih.gov/pubmed/25121506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12107
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