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Genome-wide association study combined with biological context can reveal more disease-related SNPs altering microRNA target seed sites

BACKGROUND: Emerging studies demonstrate that single nucleotide polymorphisms (SNPs) resided in the microRNA recognition element seed sites (MRESSs) in 3′UTR of mRNAs are putative biomarkers for human diseases and cancers. However, exhaustively experimental validation for the causality of MRESS SNPs...

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Detalles Bibliográficos
Publicado en:BMC Genomics
Main Authors: Wu, Di, Yang, Gang, Zhang, Lifang, Xue, Jiwei, Wen, Zhining, Li, Menglong
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246476/
https://ncbi.nlm.nih.gov/pubmed/25106527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-669
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