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SIN3A, Generally Regarded as a Transcriptional Repressor, Is Required for Induction of Gene Transcription by the Aryl Hydrocarbon Receptor

CYP1A1 bioactivates several procarcinogens and detoxifies several xenobiotic compounds. Transcription of CYP1A1 is highly induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) via the aryl hydrocarbon receptor. We recently described an RNAi high throughput screening performed in the Hepa-1 mouse hep...

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Vydáno v:J Biol Chem
Hlavní autoři: Solaimani, Parrisa, Wang, Feng, Hankinson, Oliver
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246116/
https://ncbi.nlm.nih.gov/pubmed/25305016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611236
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