Cyclopamine Modulates γ-Secretase-mediated Cleavage of Amyloid Precursor Protein by Altering Its Subcellular Trafficking and Lysosomal Degradation

Alzheimer disease (AD) is a progressive neurodegenerative disease leading to memory loss. Numerous lines of evidence suggest that amyloid-β (Aβ), a neurotoxic peptide, initiates a cascade that results in synaptic dysfunction, neuronal death, and eventually cognitive deficits. Aβ is generated by the...

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Udgivet i:J Biol Chem
Main Authors: Vorobyeva, Anna G., Lee, Randall, Miller, Sean, Longen, Charles, Sharoni, Michal, Kandelwal, Preeti J., Kim, Felix J., Marenda, Daniel R., Saunders, Aleister J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246084/
https://ncbi.nlm.nih.gov/pubmed/25281744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.591792
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