Disruption of hSWI/SNF complexes in T cells by WAS mutations distinguishes X-linked thrombocytopenia from Wiskott-Aldrich syndrome

Wiskott-Aldrich syndrome (WAS), an immunodeficiency disorder, and X-linked thrombocytopenia (XLT), a bleeding disorder, both arise from nonsynonymous mutations in WAS, which encodes a hematopoietic-specific WASp. Intriguingly, XLT evolves into WAS in some patients but not in others; yet the biologic...

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Bibliographic Details
Published in:Blood
Main Authors: Sarkar, Koustav, Sadhukhan, Sanjoy, Han, Seong-Su, Vyas, Yatin M.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2014
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246038/
https://ncbi.nlm.nih.gov/pubmed/25253772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-587642
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