Oxidative DNA damage is instrumental in hyperreplication stress-induced inviability of Escherichia coli

In Escherichia coli, an increase in the ATP bound form of the DnaA initiator protein results in hyperinitiation and inviability. Here, we show that such replication stress is tolerated during anaerobic growth. In hyperinitiating cells, a shift from anaerobic to aerobic growth resulted in appearance...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Charbon, Godefroid, Bjørn, Louise, Mendoza-Chamizo, Belén, Frimodt-Møller, Jakob, Løbner-Olesen, Anders
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245963/
https://ncbi.nlm.nih.gov/pubmed/25389264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1149
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