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Oxidative DNA damage is instrumental in hyperreplication stress-induced inviability of Escherichia coli

In Escherichia coli, an increase in the ATP bound form of the DnaA initiator protein results in hyperinitiation and inviability. Here, we show that such replication stress is tolerated during anaerobic growth. In hyperinitiating cells, a shift from anaerobic to aerobic growth resulted in appearance...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Charbon, Godefroid, Bjørn, Louise, Mendoza-Chamizo, Belén, Frimodt-Møller, Jakob, Løbner-Olesen, Anders
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245963/
https://ncbi.nlm.nih.gov/pubmed/25389264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1149
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