Optimization of transcription factor binding map accuracy utilizing knockout-mouse models

Genome-wide assessment of protein–DNA interaction by chromatin immunoprecipitation followed by massive parallel sequencing (ChIP-seq) is a key technology for studying transcription factor (TF) localization and regulation of gene expression. Signal-to-noise-ratio and signal specificity in ChIP-seq st...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Krebs, Wolfgang, Schmidt, Susanne V., Goren, Alon, De Nardo, Dominic, Labzin, Larisa, Bovier, Anton, Ulas, Thomas, Theis, Heidi, Kraut, Michael, Latz, Eicke, Beyer, Marc, Schultze, Joachim L.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
Sujets:
Gene regulation, Chromatin and Epigenetics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245947/
https://ncbi.nlm.nih.gov/pubmed/25378309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1078
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