RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation

The JmjC-containing lysine demethylase, KDM4D, demethylates di-and tri-methylation of histone H3 on lysine 9 (H3K9me3). How KDM4D is recruited to chromatin and recognizes its histone substrates remains unknown. Here, we show that KDM4D binds RNA independently of its demethylase activity. We mapped t...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Zoabi, Muhammad, Nadar-Ponniah, Prathamesh T., Khoury-Haddad, Hanan, Usaj, Marko, Budowski-Tal, Inbal, Haran, Tali, Henn, Arnon, Mandel-Gutfreund, Yael, Ayoub, Nabieh
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Gene regulation, Chromatin and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245933/
https://ncbi.nlm.nih.gov/pubmed/25378304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1021
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