PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair

Members of the lysine (K)-specific demethylase 4 (KDM4) A–D family of histone demethylases are dysregulated in several types of cancer. Here, we reveal a previously unrecognized role of KDM4D in the DNA damage response (DDR). We show that the C-terminal region of KDM4D mediates its rapid recruitment...

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Bibliografiska uppgifter
Huvudupphovsmän: Khoury-Haddad, Hanan, Guttmann-Raviv, Noga, Ipenberg, Inbal, Huggins, David, Jeyasekharan, Anand D., Ayoub, Nabieh
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2014
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932863/
https://ncbi.nlm.nih.gov/pubmed/24550317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317585111
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