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PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair
Members of the lysine (K)-specific demethylase 4 (KDM4) A–D family of histone demethylases are dysregulated in several types of cancer. Here, we reveal a previously unrecognized role of KDM4D in the DNA damage response (DDR). We show that the C-terminal region of KDM4D mediates its rapid recruitment...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3932863/ https://ncbi.nlm.nih.gov/pubmed/24550317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317585111 |
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